Collibacillosis is a bacterial infection that primarily affects animals, especially livestock. It is caused by certain strains of the bacterium Escherichia coli (E. coli). While E. coli is a normal resident of the intestinal tract in animals, pathogenic strains can cause infections when they enter other parts of the body. Collibacillosis can have significant impacts on animal health and the agricultural industry as a whole. In this article, we will explore the causes, symptoms, treatment options, and prevention measures for Collibacillosis.

Disease Name Colibacillosis
Also Known As Escherichia coli infection, E. coli infection
Definition Collibacillosis is an infectious disease caused by the bacterium Escherichia coli (E. coli). It primarily affects the gastrointestinal tract but can also lead to urinary tract infections and other systemic infections.
Causative Agent Escherichia coli (E. coli) bacteria
Mode of Transmission Consumption of contaminated food or water, contact with infected individuals, poor hygiene practices
Symptoms  Gastrointestinal symptoms: diarrhea, abdominal pain, nausea, vomiting
   Urinary tract symptoms: frequent urination, painful urination, cloudy or bloody urine
   Systemic symptoms: fever, fatigue, loss of appetite
   In severe cases, it can lead to sepsis or kidney damage
Diagnosis  Clinical examination and medical history
   Laboratory tests: stool culture, urine culture, blood tests
Treatment  Supportive care: fluid replacement, electrolyte balance
   Antibiotic therapy: appropriate antibiotics based on susceptibility testing
Prevention  Proper food handling and hygiene practices
   Safe drinking water sources
   Vaccination (if available)
   Antibiotic stewardship to prevent antimicrobial resistance
Complications  Dehydration
   Kidney damage
   Hemolytic Uremic Syndrome (HUS) in some cases
Prognosis The prognosis varies depending on the severity of the infection and the overall health of the affected individual. With appropriate treatment and supportive care, most individuals recover fully. However, severe cases can be life-threatening, especially in vulnerable populations such as young children and older adults.
References  Centers for Disease Control and Prevention (CDC)
   World Health Organization (WHO)


Collibacillosis is primarily caused by pathogenic strains of E. coli bacteria. These strains produce toxins that can damage the tissues and organs of the infected animals.


The transmission of Collibacillosis can occur through various routes. Direct contact with infected animals or their feces is a common mode of transmission. Contaminated water sources and feed, as well as contaminated equipment, can also contribute to the spread of the disease. Factors such as overcrowding, poor sanitation, and inadequate hygiene practices can increase the risk of Collibacillosis within animal populations.


Animals infected with Collibacillosis may exhibit a range of symptoms, which can vary depending on the severity of the infection and the affected organ system. Common symptoms include diarrhea, often with blood or mucus, fever, loss of appetite, dehydration, weakness, and respiratory distress. In young animals, Collibacillosis can cause septicemia, which is a severe infection of the bloodstream.


Diagnosis of Collibacillosis is typically done through laboratory testing of samples such as feces, blood, or tissue. This helps identify the presence of E. coli bacteria and determine the specific strain involved.

  • Laboratory tests include
  • Determination of Colonization
  • Haemagglutination Test
  • Raphhinose Fermentation Test
  • Mannose Binding Test

Necropsy Findings

Fibrin, Yolk Debris, or Milky Fluid in the Peritoneal Cavity in and around joints and on the surface of multiple organs.



Prevention and Control Measures:

Preventing Collibacillosis requires implementing effective control measures. Good hygiene and sanitation practices play a crucial role in reducing the risk of infection. Regular cleaning and disinfection of animal housing and equipment are essential. Providing animals with access to clean water and proper waste management are also important preventive measures.


Vaccination is an effective strategy for preventing certain strains of E. coli associated with Collibacillosis. Consultation with a veterinarian is necessary to determine the appropriate vaccination protocol for the specific animal species. Additionally, ensuring animals receive a balanced and nutritious diet helps strengthen their immune systems, making them less susceptible to infections.

  • coli antigen.


Treatment Options:


The treatment of Collibacillosis often involves the use of antibiotics to control the bacterial infection. It is crucial to consult a veterinarian for appropriate antibiotic selection and dosage, as well as to avoid the development of antibiotic resistance.

  • Tetracycline
  • Sulfas
  • Ampicillin
  • Streptomycin


Loperamide (It is adjunctive to antibiotics for diarrhea)

 Supportive Treatment

Supportive care is also essential in the management of Colibacillosis

Fluid therapy

This includes fluid therapy to address dehydration caused by diarrhea and other symptoms. In severe cases or when complications arise, surgical intervention may be necessary to remove infected tissues or address specific issues. Timely treatment and proper management strategies significantly contribute to the recovery of animals affected by Collibacillosis.

Impact on Animal Health and Industry:

Collibacillosis has a significant impact on both animal health and the agricultural industry. The disease can lead to reduced growth rates, weight loss, decreased milk production, and increased mortality rates in livestock. These factors result in substantial economic losses for farmers and can disrupt the supply of animal products in the market. Additionally, the presence of Collibacillosis in a livestock population can affect the trade and export of animals and their products, leading to further economic repercussions for the industry.

Research and Advancements:

Ongoing research is being conducted to develop better management strategies and treatment options for Collibacillosis. Scientists are studying the genetic factors that contribute to the pathogenicity of E. coli strains, aiming to identify potential targets for intervention. New antibiotic formulations and alternative therapies, such as bacteriophage therapy, are also being explored. Bacteriophages are viruses that can specifically target and kill bacteria, offering a potential alternative to traditional antibiotics. Moreover, advancements in diagnostic techniques, such as polymerase chain reaction (PCR), are improving the accuracy and speed of Collibacillosis detection, enabling prompt and targeted treatment.



Collibacillosis is a significant concern for animal health and the agricultural industry. Understanding the causes, symptoms, treatment options, and prevention measures is crucial for effective management and control of the disease. By prioritizing hygiene, vaccination, and proper nutrition, we can reduce the incidence of Collibacillosis in livestock populations. Ongoing research and advancements in diagnostic and treatment methods offer hope for better outcomes in the future.


2 thoughts on “Collibacillosis”

Leave a Comment